Compatibility: Sometimes, the application might be facing issues with your operating system, therefore, it is always a good idea to run the compatibility troubleshooter for the application and let it select the best settings for you.Also, if the versions of the mods and the F4SE application coincide it can cause issues with the application. Conflicting Mods: Another possibility is that the mods that you have installed might be conflicting with the F4SE complication due to them being outdated or malfunctioning.Therefore, it is recommended to update the F4SE application. It is possible that the Creation Club updated and is now preventing you from using the F4SE application. Updates: Developers mostly don’t support third-party modding facilities for their games and therefore try to prevent those in every update of the game.